As of September 22, 2014, the NIDDK Clearinghouses Publication Catalog and Image
Library sites will be unavailable until further notice.
Although you will not be able to order publications, you can view, download, and print them by using the links below.
For urgent matters, please send an email to firstname.lastname@example.org.
|Brand Name||Generic Name|
|__ Glucophage (GLOO-coh-fahj)||__ metformin (met-FOR-min)|
|__ Glucophage XR||__ metformin-long-acting|
|__ Riomet (RY-oh-met)||__ metformin-liquid|
The American Diabetes Association recommends metformin (Glucophage, Glucophage XR, Riomet) as the first choice of diabetes medicine for most people with type 2 diabetes. Metformin can be taken alone or with other diabetes medicines. See Insert K for information about combination pills that contain both metformin and another diabetes medicine.
What does this type of medicine do?
This type of medicine, which comes in pill or liquid form, lowers the amount of glucose made by your liver. Then your blood glucose levels don’t go too high. This type of medicine also helps treat insulin resistance. With insulin resistance, your body doesn’t use insulin the way it should. When your insulin works properly, your blood glucose levels stay on target and your cells get the energy they need. This type of medicine improves your cholesterol levels. It also may help you lose weight.
Who should not take Glucophage, Glucophage XR, or Riomet?
Talk with your doctor about whether to take this type of medicine if
- you have advanced kidney or liver disease
- you drink excessive amounts of alcoholic beverages
- you are pregnant, planning to get pregnant, or breastfeeding
What are the possible side effects?
This type of pill doesn't cause low blood glucose by itself. But your risk of having low blood glucose goes up if you also take
- diabetes pills that cause low blood glucose
Your doctor may ask you to take a lower dose of your other diabetes medicines while you take this type of pill.
You may have nausea, diarrhea, or an upset stomach when you first start taking this type of medicine. These side effects are likely to go away after a while.
Rarely, a serious condition called lactic acidosis occurs as a side effect of taking this medicine. Call your doctor right away if you
- become weak and tired
- become dizzy
- feel very cold
- have trouble breathing
- have unusual muscle pain and stomach problems
- have a sudden change in the speed or steadiness of your heartbeat
Sometimes you'll need to stop taking this type of medicine for a short time so you can avoid developing lactic acidosis. If you have severe vomiting, diarrhea, or a fever, or if you can't keep fluids down, call your doctor right away. You should also talk with your doctor well ahead of time about stopping this type of medicine if
- you'll be having special x rays that require an injection of dye
- you'll be having surgery
Your doctor will tell you when it's safe to start taking your medicine again.
Page last updated February 16, 2012